Recurrent PRDM10 Gene Fusions in Undifferentiated Pleomorphic Sarcoma

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Recurrent PRDM10 gene fusions in undifferentiated pleomorphic sarcoma.

PURPOSE Undifferentiated pleomorphic sarcoma (UPS) is defined as a sarcoma with cellular pleomorphism and no identifiable line of differentiation. It is typically a high-grade lesion with a metastatic rate of about one third. No tumor-specific rearrangement has been identified, and genetic markers that could be used for treatment stratification are lacking. We performed transcriptome sequencing...

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ژورنال

عنوان ژورنال: Clinical Cancer Research

سال: 2014

ISSN: 1078-0432,1557-3265

DOI: 10.1158/1078-0432.ccr-14-2399